Structure and function of SH2 domains
- PMID: 7883800
- DOI: 10.1242/jcs.1994.supplement_18.14
Structure and function of SH2 domains
Abstract
In order for cells to respond to their environment, a series of regulated molecular events has to take place. External signalling molecules bind to cellular receptors and thereby trigger the activation of multiple intracellular pathways, which modify cellular phenotypes. The cell-surface receptors for a wide range of polypeptide hormones possess protein tyrosine kinase activity, which is induced by binding of the appropriate extracellular ligand. Tyrosine phosphorylation can act as a molecular switch, by initiating the recruitment of cytoplasmic effector molecules containing Src homology (SH) 2 domains, to activated receptors. These SH2-containing proteins, in turn, regulate intracellular signalling pathways. Here, we discuss the role of tyrosine phosphorylation in triggering signalling pathways, as well as the functions of SH2 domains, which mediate these events through phosphotyrosine-dependent protein-protein interactions.
Similar articles
-
Tyrosine kinase signalling pathways.Princess Takamatsu Symp. 1994;24:303-22. Princess Takamatsu Symp. 1994. PMID: 8983084 Review.
-
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.Science. 1991 May 3;252(5006):668-74. doi: 10.1126/science.1708916. Science. 1991. PMID: 1708916
-
Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways.Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29;340(1293):279-85. doi: 10.1098/rstb.1993.0069. Philos Trans R Soc Lond B Biol Sci. 1993. PMID: 8103930 Review.
-
Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains.Eur J Immunol. 1995 Oct;25(10):2978-84. doi: 10.1002/eji.1830251040. Eur J Immunol. 1995. PMID: 7589101
-
Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.Oncogene. 1998 Jul 16;17(2):255-60. doi: 10.1038/sj.onc.1201907. Oncogene. 1998. PMID: 9674711
Cited by
-
FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.EMBO J. 1997 May 1;16(9):2376-83. doi: 10.1093/emboj/16.9.2376. EMBO J. 1997. PMID: 9171351 Free PMC article.
-
The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis.PLoS Pathog. 2010 Feb 12;6(2):e1000769. doi: 10.1371/journal.ppat.1000769. PLoS Pathog. 2010. PMID: 20169182 Free PMC article.
-
SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.Am J Hum Genet. 2013 Jul 11;93(1):150-7. doi: 10.1016/j.ajhg.2013.05.023. Epub 2013 Jun 27. Am J Hum Genet. 2013. PMID: 23810379 Free PMC article.
-
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents.Clin Sci (Lond). 2021 Jul 16;135(13):1545-1556. doi: 10.1042/CS20201367. Clin Sci (Lond). 2021. PMID: 34192314 Free PMC article. Review.
-
The application of FAST-NMR for the identification of novel drug discovery targets.Drug Discov Today. 2008 Feb;13(3-4):172-9. doi: 10.1016/j.drudis.2007.11.001. Drug Discov Today. 2008. PMID: 18275915 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Miscellaneous