Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome

doi:10.1038/bjc.1995.119

Comparative Study

. 1995 Mar;71(3):614-6.

doi: 10.1038/bjc.1995.119.

Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome

S Dorudi¹, A M Hanby, R Poulsom, J Northover, I R Hart

Affiliations

PMID: 7880746
PMCID: PMC2033614
DOI: 10.1038/bjc.1995.119

Free PMC article

Comparative Study

Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome

S Dorudi et al. Br J Cancer. 1995 Mar.

Free PMC article

. 1995 Mar;71(3):614-6.

doi: 10.1038/bjc.1995.119.

Authors

S Dorudi¹, A M Hanby, R Poulsom, J Northover, I R Hart

Affiliation

¹ Richard Dimbleby/ICRF Laboratory, St. Thomas' Hospital, London, UK.

PMID: 7880746
PMCID: PMC2033614
DOI: 10.1038/bjc.1995.119

Abstract

A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients.

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References

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[1] Mol Cell Biol. 1983 Oct;3(10):1783-91 - PubMed

[2] Mol Cell Biol. 1983 Oct;3(10):1783-91 - PubMed

[3] Ann R Coll Surg Engl. 1994 Jan;76(1):59-64 - PubMed

[4] Ann R Coll Surg Engl. 1994 Jan;76(1):59-64 - PubMed

[5] Annu Rev Biochem. 1990;59:237-52 - PubMed

[6] Annu Rev Biochem. 1990;59:237-52 - PubMed

[7] J Cell Biol. 1991 Apr;113(1):173-85 - PubMed

[8] J Cell Biol. 1991 Apr;113(1):173-85 - PubMed

[9] Cell. 1991 Jul 12;66(1):107-19 - PubMed

[10] Cell. 1991 Jul 12;66(1):107-19 - PubMed

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Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome

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Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome

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