Review
doi: 10.1016/0968-0004(94)90133-3.
The ins and outs of Raf kinases
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- PMID: 7855890
- DOI: 10.1016/0968-0004(94)90133-3
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Review
The ins and outs of Raf kinases
Trends Biochem Sci.
1994 Nov.
Abstract
Raf kinases are signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect growth factor receptors with transcription factors. The connection involves a cascade of protein kinases that is essential for cellular proliferation and differentiation of species ranging from worms to humans. This cascade also mediates transformation by most oncogenes.
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