doi: 10.1126/science.7846532.
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle
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- PMID: 7846532
- DOI: 10.1126/science.7846532
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Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle
Science.
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Abstract
Infection of cattle with the protozoan parasite Theileria parva results in a fatal lymphoproliferative syndrome that is associated with the overexpression of casein kinase II. The role of this enzyme in the pathogenesis of lymphoproliferative disorders was investigated by expressing the catalytic subunit in lymphocytes of transgenic mice. Adult transgenic mice displayed a stochastic propensity to develop lymphoma; co-expression of a c-myc transgene in addition to casein kinase II resulted in neonatal leukemia. Thus, the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc.
Comment in
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Casein kinase II in theileriosis.Science. 1995 Feb 10;267(5199):834-6. doi: 10.1126/science.7846527. Science. 1995. PMID: 7846527 Review. No abstract available.
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