doi: 10.1083/jcb.128.3.405.
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
Affiliations
- PMID: 7844154
- PMCID: PMC2120359
- DOI: 10.1083/jcb.128.3.405
Item in Clipboard
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
J Cell Biol.
1995 Feb.
Abstract
Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase.
Similar articles
-
The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.EMBO J. 1997 Jul 16;16(14):4317-32. doi: 10.1093/emboj/16.14.4317. EMBO J. 1997. PMID: 9250676 Free PMC article.
-
Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium.J Biol Chem. 1997 Sep 19;272(38):23690-5. doi: 10.1074/jbc.272.38.23690. J Biol Chem. 1997. PMID: 9295311
-
CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.J Cell Biol. 1994 Sep;126(6):1537-45. doi: 10.1083/jcb.126.6.1537. J Cell Biol. 1994. PMID: 8089184 Free PMC article.
-
Adenylyl cyclase expression and regulation during the differentiation of Dictyostelium discoideum.IUBMB Life. 2004 Sep;56(9):541-6. doi: 10.1080/15216540400013887. IUBMB Life. 2004. PMID: 15590560 Review.
-
G protein pathways: signal processing by effectors.Mol Cell Endocrinol. 1994 Apr;100(1-2):65-70. doi: 10.1016/0303-7207(94)90280-1. Mol Cell Endocrinol. 1994. PMID: 8056160 Review. No abstract available.
Cited by
-
The internal phosphodiesterase RegA is essential for the suppression of lateral pseudopods during Dictyostelium chemotaxis.Mol Biol Cell. 2000 Aug;11(8):2803-20. doi: 10.1091/mbc.11.8.2803. Mol Biol Cell. 2000. PMID: 10930471 Free PMC article.
-
Mitogen-activated protein kinase regulation of the phosphodiesterase RegA in early Dictyostelium development.Microbiology (Reading). 2020 Feb;166(2):129-140. doi: 10.1099/mic.0.000868. Microbiology (Reading). 2020. PMID: 31730032 Free PMC article.
-
Multiple signalling pathways connect chemoattractant receptors and calcium channels in Dictyostelium.J Muscle Res Cell Motil. 2002;23(7-8):853-65. doi: 10.1023/a:1024496232604. J Muscle Res Cell Motil. 2002. PMID: 12952083
-
Control of host cell phosphorylation by legionella pneumophila.Front Microbiol. 2011 Apr 4;2:64. doi: 10.3389/fmicb.2011.00064. eCollection 2011. Front Microbiol. 2011. PMID: 21747787 Free PMC article.
-
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.Mol Biol Cell. 1999 Sep;10(9):2829-45. doi: 10.1091/mbc.10.9.2829. Mol Biol Cell. 1999. PMID: 10473630 Free PMC article.
References
Publication types
MeSH terms
Substances
Associated data
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous
