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. 1995 Feb;63(2):596-600.
doi: 10.1128/iai.63.2.596-600.1995.

Humoral and cell-mediated immunity to the Plasmodium falciparum ring-infected erythrocyte surface antigen in an adult population exposed to highly endemic malaria

H P Beck  1 , I Felger, B Genton, N Alexander, F al-Yaman, R F Anders, M Alpers
Affiliations

Humoral and cell-mediated immunity to the Plasmodium falciparum ring-infected erythrocyte surface antigen in an adult population exposed to highly endemic malaria

H P Beck et al. Infect Immun. 1995 Feb.

Abstract

A parasitological and immunological survey was carried out in an area in Papua New Guinea highly endemic for malaria. Two hundred fourteen adult individuals were selected for studies to assess their immune responses against the malaria vaccine candidate ring-infected erythrocyte surface antigen (RESA). Total immunoglobulin G (IgG) antibodies directed against RESA as well as specific IgG1, IgG2, and IgG3 antibodies were determined. Humoral responses directed against RESA were frequent in all IgG subclasses. Only IgG3 responses were found to be age dependent. Total anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast, cytophilic antibodies (IgG1 and IgG3) were associated with reduced Plasmodium falciparum prevalence and reduced health center attendance. T-cell proliferation in general was low and very infrequent. No correlation between humoral and cellular immune responses could be found. Parasite density, parasite prevalence, and health center visits tended to be reduced in individuals with good humoral and cell-mediated immune responses.

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References

    1. Infect Immun. 1991 Mar;59(3):1183-7 - PubMed
    1. Trans R Soc Trop Med Hyg. 1992 Sep-Oct;86(5):486-90 - PubMed
    1. Immunology. 1991 May;73(1):1-7 - PubMed
    1. Infect Immun. 1991 Jul;59(7):2403-11 - PubMed
    1. Trans R Soc Trop Med Hyg. 1991 Jul-Aug;85(4):436-43 - PubMed

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