Parvalbumin is a marker of ALS-resistant motor neurons
- PMID: 7766841
- DOI: 10.1097/00001756-199502000-00011
Parvalbumin is a marker of ALS-resistant motor neurons
Abstract
The selective vulnerability of limb and bulbar motor neurons is a hallmark of degenerative human motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Currently, there are no known molecular characteristics to distinguish between motor neuron pools which are highly susceptible to degeneration in ALS and those populations which are resistant. Using in situ hybridization on adult rat tissue, we demonstrated that ALS-resistant motor pools robustly express mRNA for the calcium binding protein parvalbumin, while no measurable parvalbumin expression is found in ALS-sensitive motor neuron populations. In contrast, mRNA expression for each of several other calcium binding proteins such as calbindin-D28K, calretinin and calmodulin appears similar in the various motor pools. Thus, parvalbumin represents a biochemical marker of ALS-resistant motor neurons, and may provide insight into the mechanisms of resistance of certain motor neurons to disease.
Similar articles
-
The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis.Ann Neurol. 1994 Dec;36(6):846-58. doi: 10.1002/ana.410360608. Ann Neurol. 1994. PMID: 7998770
-
Calcium binding proteins in motoneurons at low and high risk for degeneration in ALS.Neuroreport. 2000 Oct 20;11(15):3305-8. doi: 10.1097/00001756-200010200-00009. Neuroreport. 2000. PMID: 11059892
-
Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.Neuroscience. 1999 Jan;88(2):521-34. doi: 10.1016/s0306-4522(98)00226-7. Neuroscience. 1999. PMID: 10197772
-
Calcium: the Darth Vader of ALS.Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 Mar;2 Suppl 1:S47-54. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001. PMID: 11465925 Review.
-
Increased intracellular calcium triggered by immune mechanisms in amyotrophic lateral sclerosis.Clin Neurosci. 1995-1996;3(6):368-74. Clin Neurosci. 1995. PMID: 9021258 Review.
Cited by
-
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.Exp Neurol. 2014 Nov;261:1-9. doi: 10.1016/j.expneurol.2014.06.003. Epub 2014 Jun 8. Exp Neurol. 2014. PMID: 24918341 Free PMC article.
-
Effects of peripheral nerve injury on parvalbumin expression in adult rat dorsal root ganglion neurons.BMC Neurosci. 2015 Dec 16;16:93. doi: 10.1186/s12868-015-0232-9. BMC Neurosci. 2015. PMID: 26674138 Free PMC article.
-
Calcium dynamics and buffering in oculomotor neurones from mouse that are particularly resistant during amyotrophic lateral sclerosis (ALS)-related motoneurone disease.J Physiol. 2000 Jun 1;525 Pt 2(Pt 2):433-45. doi: 10.1111/j.1469-7793.2000.t01-1-00433.x. J Physiol. 2000. PMID: 10835045 Free PMC article.
-
TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury.Exp Neurol. 2012 Dec;238(2):93-102. doi: 10.1016/j.expneurol.2012.08.004. Epub 2012 Aug 19. Exp Neurol. 2012. PMID: 22921461 Free PMC article.
-
Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures.Brain Res. 2012 Apr 11;1448:153-62. doi: 10.1016/j.brainres.2012.02.005. Epub 2012 Feb 9. Brain Res. 2012. PMID: 22370146 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous