Review
doi: 10.1016/S0168-9525(00)89010-1.
Regulators of cell death
Affiliations
- PMID: 7732571
- DOI: 10.1016/S0168-9525(00)89010-1
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Review
Regulators of cell death
Trends Genet.
1995 Mar.
Abstract
A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death, Bax, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types.
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