Review
doi: 10.1016/0163-7258(94)90023-x.
Coley's toxins, tumor necrosis factor and cancer research: a historical perspective
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- PMID: 7724661
- DOI: 10.1016/0163-7258(94)90023-x
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Review
Coley's toxins, tumor necrosis factor and cancer research: a historical perspective
Pharmacol Ther.
1994.
Abstract
As far back as the 1700s, it was recorded that certain infectious disease processes could exert a beneficial therapeutic effect upon malignancy. Most prominent among the numerous deliberate efforts made to take advantage of these observations was that of a pioneering New York surgeon, William B. Coley, active career 1891-1936. Using a bacterial vaccine to treat primarily inoperable sarcoma. Coley accomplished a cure rate of better than 10%. This review examines the history of these efforts and presents a discussion of their corresponding relevance to present day immunotherapy.
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