Review
doi: 10.1016/0968-0004(93)90069-y.
Cyclosporin A, FK506 and rapamycin: more than just immunosuppression
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- PMID: 7694398
- DOI: 10.1016/0968-0004(93)90069-y
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Review
Cyclosporin A, FK506 and rapamycin: more than just immunosuppression
Trends Biochem Sci.
1993 Sep.
Abstract
The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
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