doi: 10.1016/0378-1119(93)90157-x.
Design of specific immunogens using filamentous phage as the carrier
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- PMID: 7685305
- DOI: 10.1016/0378-1119(93)90157-x
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Design of specific immunogens using filamentous phage as the carrier
Gene.
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Abstract
Earlier, we developed an expression vector allowing exposure of short peptides on the surface of bacteriophage M13. It was used to obtain a recombinant phage carrying an antigenic determinant of HIV1 p17 Gag protein. Immunoglobulin elicited by immunizing rabbits with the phage reacted with the 17-kDa core protein of the virus and with its polyprotein precursor, p55, on Western blots of HIV1 viral proteins. The results of present experiments may be useful in vaccine development.
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