Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support
- PMID: 7683220
Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support
Abstract
Endogenous cytokines are thought to mediate numerous biologic processes and may account for some adverse effects experienced following the administration of recombinant proteins. This study describes the pattern of endogenous cytokine exposure following high-dose chemotherapy. Blood concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), macrophage colony-stimulating factor (M-CSF), and erythropoietin (EPO) were measured by enzyme-linked immunosorbent assay (ELISA) methods in 68 patients receiving the same ablative chemotherapy regimen (cyclophosphamide, cisplatin, carmustine). Patients were grouped according to cellular support (autologous bone marrow [BM] CSF-primed peripheral blood progenitor cells [PBPCs]) and prescribed growth factor (recombinant human granulocyte or granulocyte-macrophage colony-stimulating factor [rHuG-CSF or rHuGM-CSF]). Leukocyte reconstitution was most accelerated in the groups treated with PBPCs and rHuG-CSF. IL-6, M-CSF, and TNF-alpha concentrations were higher in the groups treated with rHuGM-CSF and without PBPCs. Maximal endogenous cytokine concentrations occurred approximately 12 days after BM reinfusion. High concentrations of EPO occurred in patients experiencing significant hypotension despite routine transfusions for hematocrit < 42%. High M-CSF and IL-6 levels were associated with increased platelet transfusion requirements. Concentrations of all four cytokines were significantly higher in patients experiencing renal or hepatic toxicity, with elevations occurring in a predictable sequence and M-CSF elevations occurring first. This report shows that endogenous cytokine concentrations may be influenced by either cellular or CSF support and are associated with differences in platelet reconstitution and organ toxicity.
Similar articles
-
Comparative effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy.Blood. 1993 Apr 1;81(7):1709-19. Blood. 1993. PMID: 7681699
-
Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors: G-CSF, GM-CSF, IL-1, IL-2, M-CSF.Ann Hematol. 1993 Dec;67(6):267-76. doi: 10.1007/BF01696346. Ann Hematol. 1993. PMID: 7506580 Clinical Trial.
-
Mobilization of peripheral blood progenitor cells by chemotherapy and granulocyte-macrophage colony-stimulating factor for hematologic support after high-dose intensification for breast cancer.Blood. 1992 Jun 1;79(11):3036-44. Blood. 1992. PMID: 1350229
-
Source of stem cells impacts on hematopoietic recovery after high-dose chemotherapy.Bone Marrow Transplant. 1995 Jun;15(6):923-7. Bone Marrow Transplant. 1995. PMID: 7581092 Review.
-
[Clinical application of hematopoietic growth factor (IL-3, G-CSF, GM-CSF, and EPO)].Nihon Rinsho. 1992 Aug;50(8):1967-72. Nihon Rinsho. 1992. PMID: 1279240 Review. Japanese.
Cited by
-
Noninfectious pulmonary complications of haematopoietic stem cell transplantation.Eur Respir Rev. 2020 Jun 23;29(156):190119. doi: 10.1183/16000617.0119-2019. Print 2020 Jun 30. Eur Respir Rev. 2020. PMID: 32581138 Free PMC article. Review.
-
Engraftment Syndrome: Clinical Features and Predictive Factors in Autologous Stem Cell Transplant.Indian J Hematol Blood Transfus. 2018 Jul;34(3):448-453. doi: 10.1007/s12288-017-0899-4. Epub 2017 Nov 15. Indian J Hematol Blood Transfus. 2018. PMID: 30127551 Free PMC article.
-
Alcohol Misuse Link to POEMS Syndrome in a Patient.Cancers (Basel). 2017 Sep 23;9(10):129. doi: 10.3390/cancers9100129. Cancers (Basel). 2017. PMID: 28946631 Free PMC article.
-
Adaptive Immune Response Impairs the Efficacy of Autologous Transplantation of Engineered Stem Cells in Dystrophic Dogs.Mol Ther. 2016 Nov;24(11):1949-1964. doi: 10.1038/mt.2016.163. Epub 2016 Aug 10. Mol Ther. 2016. PMID: 27506452 Free PMC article.
-
Engraftment syndrome: double-edged sword of hematopoietic cell transplants.Bone Marrow Transplant. 2015 Apr;50(4):469-75. doi: 10.1038/bmt.2014.296. Epub 2015 Jan 12. Bone Marrow Transplant. 2015. PMID: 25581406 Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials