Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
- PMID: 7679952
- DOI: 10.1016/0092-8674(93)90074-z
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
Abstract
We constructed a transgenic mouse model that mimics the human autoimmune disease multiple sclerosis in its spontaneous induction and pathology. Transgenic mice were constructed expressing genes encoding a rearranged T cell receptor specific for myelin basic protein (MBP). T cell tolerance was not induced in the periphery, and functional, autoreactive T cells were found in the spleen and lymph nodes of these mice. Transgenic mice developed experimental allergic encephalomyelitis (EAE) following immunization with MBP and adjuvant plus pertussis toxin as well as with administration of pertussis toxin alone. Spontaneous EAE can develop in transgenic mice housed in a non-sterile facility but not in those maintained in a sterile, specific pathogen-free facility. This model system affords a unique opportunity to dissect the genetic and environmental variables that may contribute to the development of spontaneous autoimmune disease.
Similar articles
-
Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein.Immunol Rev. 1999 Jun;169(1):147-59. doi: 10.1111/j.1600-065x.1999.tb01313.x. Immunol Rev. 1999. PMID: 10450515 Free PMC article. Review.
-
Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE).J Exp Med. 1996 Nov 1;184(5):1609-17. doi: 10.1084/jem.184.5.1609. J Exp Med. 1996. PMID: 8920851 Free PMC article.
-
Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein.J Immunol. 2001 May 1;166(9):5773-81. doi: 10.4049/jimmunol.166.9.5773. J Immunol. 2001. PMID: 11313421
-
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice.Cell. 1994 Aug 12;78(3):399-408. doi: 10.1016/0092-8674(94)90419-7. Cell. 1994. PMID: 7520367
-
Initiation and regulation of CNS autoimmunity.Crit Rev Immunol. 1997;17(5-6):469-80. Crit Rev Immunol. 1997. PMID: 9419434 Review.
Cited by
-
Autoimmune Disorders of the Nervous System: Pathophysiology, Clinical Features, and Therapy.Front Neurol. 2021 Apr 14;12:664664. doi: 10.3389/fneur.2021.664664. eCollection 2021. Front Neurol. 2021. PMID: 33935958 Free PMC article. Review.
-
Psychobiotic Properties of Lactiplantibacillus plantarum in Neurodegenerative Diseases.Int J Mol Sci. 2024 Aug 31;25(17):9489. doi: 10.3390/ijms25179489. Int J Mol Sci. 2024. PMID: 39273435 Free PMC article. Review.
-
Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen.J Autoimmun. 2013 Aug;44:21-33. doi: 10.1016/j.jaut.2013.06.003. Epub 2013 Jun 28. J Autoimmun. 2013. PMID: 23810578 Free PMC article.
-
The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis.J Neuroinflammation. 2013 May 24;10:67. doi: 10.1186/1742-2094-10-67. J Neuroinflammation. 2013. PMID: 23705890 Free PMC article.
-
Modeling the heterogeneity of multiple sclerosis in animals.Trends Immunol. 2013 Aug;34(8):410-22. doi: 10.1016/j.it.2013.04.006. Epub 2013 May 21. Trends Immunol. 2013. PMID: 23707039 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
