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. 1995 Sep;38(3):463-5.
doi: 10.1002/ana.410380319.

Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians

B O Osuntokun  1 , A Sahota, A O Ogunniyi, O Gureje, O Baiyewu, A Adeyinka, S O Oluwole, O Komolafe, K S Hall, F W Unverzagt, et al.
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Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians

B O Osuntokun et al. Ann Neurol. 1995 Sep.

Abstract

As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans.

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