Review
doi: 10.1016/0955-0674(95)80087-5.
The SMC family: from chromosome condensation to dosage compensation
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- PMID: 7662362
- DOI: 10.1016/0955-0674(95)80087-5
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Review
The SMC family: from chromosome condensation to dosage compensation
Curr Opin Cell Biol.
1995 Jun.
Abstract
Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.
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