Comparative Study
doi: 10.1016/0896-6273(95)90040-3.
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
Affiliations
- PMID: 7646890
- DOI: 10.1016/0896-6273(95)90040-3
Item in Clipboard
Comparative Study
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
Neuron.
1995 Aug.
Free article
Abstract
A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predicted amphipathic alpha helix typical of the lipid-binding domain in apolipoproteins. We show this protein, which we call synelfin, to be the homolog of the human non-A beta component (and its precursor) recently purified from Alzheimer's disease amyloid. We suggest this highly conserved protein may serve a novel function critical to the regulation of vertebrate neural plasticity.
Similar articles
-
Synelfin regulation during the critical period for song learning in normal and isolated juvenile zebra finches.Neurobiol Learn Mem. 1997 Nov;68(3):271-84. doi: 10.1006/nlme.1997.3795. Neurobiol Learn Mem. 1997. PMID: 9398589
-
Expression of the GABA(A) receptor gamma4-subunit gene in discrete nuclei within the zebra finch song system.Neuroscience. 2008 Nov 11;157(1):143-52. doi: 10.1016/j.neuroscience.2008.08.057. Epub 2008 Sep 6. Neuroscience. 2008. PMID: 18824085
-
Dynamic gene expression in the song system of zebra finches during the song learning period.Dev Neurobiol. 2015 Dec;75(12):1315-38. doi: 10.1002/dneu.22286. Epub 2015 Mar 20. Dev Neurobiol. 2015. PMID: 25787707 Free PMC article.
-
Role of gene regulation in song circuit development and song learning.J Neurobiol. 1997 Nov;33(5):549-71. J Neurobiol. 1997. PMID: 9369459 Review.
-
Matters of life and death in the songbird forebrain.J Neurobiol. 1992 Nov;23(9):1172-91. doi: 10.1002/neu.480230909. J Neurobiol. 1992. PMID: 1469383 Review.
Cited by
-
Therapeutic Potential of αS Evolvability for Neuropathic Gaucher Disease.Biomolecules. 2021 Feb 15;11(2):289. doi: 10.3390/biom11020289. Biomolecules. 2021. PMID: 33672048 Free PMC article.
-
Vesicle trafficking and lipid metabolism in synucleinopathy.Acta Neuropathol. 2021 Apr;141(4):491-510. doi: 10.1007/s00401-020-02177-z. Epub 2020 Jun 30. Acta Neuropathol. 2021. PMID: 32607605 Free PMC article. Review.
-
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.J Neurosci. 2000 Sep 1;20(17):6365-73. doi: 10.1523/JNEUROSCI.20-17-06365.2000. J Neurosci. 2000. PMID: 10964942 Free PMC article.
-
Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids.Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11321-6. doi: 10.1073/pnas.1734008100. Epub 2003 Sep 17. Proc Natl Acad Sci U S A. 2003. PMID: 13679584 Free PMC article.
-
Residual structure, backbone dynamics, and interactions within the synuclein family.J Mol Biol. 2007 Sep 21;372(3):689-707. doi: 10.1016/j.jmb.2007.07.008. Epub 2007 Jul 17. J Mol Biol. 2007. PMID: 17681534 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
