Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1995;121(7):413-8.
doi: 10.1007/BF01212948.

Composition and posttranslational modification of individual collagen chains from osteosarcomas and osteofibrous dysplasias

H W Lehmann  1 , E Wolf, K Röser, M Bodo, G Delling, P K Müller
Affiliations
Comparative Study

Composition and posttranslational modification of individual collagen chains from osteosarcomas and osteofibrous dysplasias

H W Lehmann et al. J Cancer Res Clin Oncol. 1995.

Abstract

The composition of collagen was analyzed and the degree of lysyl hydroxylation of individual collagen chains was determined in four osteosarcomas and two osteofibrous dysplasias. In addition, the tumor proliferation (number of mitoses, proliferating-nuclear-antigen-positive cells, MIB) as well as the response to chemotherapy (morphological regression grade) were checked. All tumors contained a high proportion of collagen III and, in all but one osteosarcoma, pepsin-extracted collagens I and III were overmodified. Furthermore, the proportion of diglycosides in collagen I was about four times higher than in controls. The collagen composition and modification resembled those of bones at early stages of human development. One osteosarcoma and both osteofibrous dysplasias were in the normal range of lysyl hydroxylation. There was no correlation between the collagen properties and the histopathological marker of tumor proliferation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochem J. 1992 Mar 1;282 ( Pt 2):313-8 - PubMed
    1. Clin Chim Acta. 1973 Aug 30;47(2):289-94 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Eur J Pediatr Surg. 1992 Oct;2(5):281-4 - PubMed
    1. J Natl Cancer Inst. 1982 Nov;69(5):1009-16 - PubMed

Publication types

MeSH terms

LinkOut - more resources