Endothelial cell-to-cell junctions
- PMID: 7615160
Endothelial cell-to-cell junctions
Abstract
The endothelium forms the main barrier to the passage of macromolecules and circulating cells from blood to tissues. Endothelial permeability is in large part regulated by intercellular junctions. These are complex structures formed by transmembrane adhesive molecules linked to a network of cytoplasmic/cytoskeletal proteins. At least four different types of endothelial junctions have been described: tight junctions, gap junctions, adherence junctions and syndesmos. These organelles have some features and components in common with epithelial cells but there are also some that are specific for the endothelium. The mechanisms that regulate the opening and closing of endothelial junctions are still obscure. It is conceivable that inflammatory agents increase permeability by binding to specific receptors generating intracellular signals, which in turn cause cytoskeletal reorganization and opening of interendothelial cell gaps. Endothelial junctions also control leukocyte extravasation. Once leukocytes have adhered to the endothelium, a coordinated opening of interendothelial cell junctions occurs. The mechanism by which this takes place is unknown, but it might present characteristics similar to that triggered by soluble mediators.
Similar articles
-
Molecular organization and functional regulation of cell to cell junctions in the endothelium.Thromb Haemost. 1995 Jul;74(1):309-12. Thromb Haemost. 1995. PMID: 8578477 Review.
-
Endothelial cell-to-cell junctions. Structural characteristics and functional role in the regulation of vascular permeability and leukocyte extravasation.Baillieres Clin Haematol. 1993 Sep;6(3):539-58. doi: 10.1016/s0950-3536(05)80187-8. Baillieres Clin Haematol. 1993. PMID: 8025343 Review.
-
Adhesive proteins at endothelial cell-to-cell junctions and leukocyte extravasation.Haemostasis. 1996 Oct;26 Suppl 4:210-9. doi: 10.1159/000217301. Haemostasis. 1996. PMID: 8979126 Review.
-
[The development of endothelial cell-to-cell junctions].Sheng Li Ke Xue Jin Zhan. 1998 Oct;29(4):314-8. Sheng Li Ke Xue Jin Zhan. 1998. PMID: 12501659 Review. Chinese.
-
Structure of intercellular junctions in the endothelium.Therapie. 1997 Sep-Oct;52(5):395-8. Therapie. 1997. PMID: 9501564 Review.
Cited by
-
Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches.Int J Mol Sci. 2021 Apr 8;22(8):3850. doi: 10.3390/ijms22083850. Int J Mol Sci. 2021. PMID: 33917744 Free PMC article. Review.
-
Erythropoietin prevents blood brain barrier damage induced by focal cerebral ischemia in mice.Neurochem Res. 2007 Dec;32(12):2132-41. doi: 10.1007/s11064-007-9387-9. Epub 2007 Jun 12. Neurochem Res. 2007. PMID: 17562165
-
Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction.Eur J Pharmacol. 2019 Dec 15;865:172795. doi: 10.1016/j.ejphar.2019.172795. Epub 2019 Nov 13. Eur J Pharmacol. 2019. PMID: 31733211 Free PMC article.
-
The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of beta-1,6-GlcNAc branching on HUVEC conformation.Mol Cell Biochem. 2010 Jul;340(1-2):143-52. doi: 10.1007/s11010-010-0411-z. Epub 2010 Mar 5. Mol Cell Biochem. 2010. PMID: 20204678
-
Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells.Front Biosci (Landmark Ed). 2020 Jan 1;25(2):283-298. doi: 10.2741/4807. Front Biosci (Landmark Ed). 2020. PMID: 31585890 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources
Research Materials
Miscellaneous