Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis
- PMID: 7557389
- DOI: 10.1101/gad.9.19.2373
Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis
Abstract
The mechanisms that underlie the segregation of muscle founder cells in the Drosophila embryo are undefined. We show that the proneural gene lethal of scute (l'sc) is expressed in clusters of cells in the somatic mesoderm, from which individual muscle progenitors are singled out by progressive restriction of l'sc expression. Coexpression of l'sc and S59 (a putative muscle identity gene) in a subset of muscle progenitors shows that muscle founders are produced by division of muscle progenitors. In neurogenic mutant embryos the restriction of l'sc expression fails and all cells in a cluster coexpress l'sc and S59. Loss-of-function and overexpression phenotypes indicate a role for l'sc in the segregation of muscle progenitors and the formation of the muscle pattern.
Similar articles
-
Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm.Genes Dev. 1998 Dec 15;12(24):3910-22. doi: 10.1101/gad.12.24.3910. Genes Dev. 1998. PMID: 9869644 Free PMC article.
-
A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L'sc and Su(H) to promote the neuroepithelial to neuroblast transition.PLoS Genet. 2023 Oct 23;19(10):e1010991. doi: 10.1371/journal.pgen.1010991. eCollection 2023 Oct. PLoS Genet. 2023. PMID: 37871020 Free PMC article.
-
Control of early neurogenesis of the Drosophila brain by the head gap genes tll, otd, ems, and btd.Dev Biol. 1997 Feb 15;182(2):270-83. doi: 10.1006/dbio.1996.8475. Dev Biol. 1997. PMID: 9070327
-
The achaete-scute complex: generation of cellular pattern and fate within the Drosophila nervous system.FASEB J. 1994 Jul;8(10):714-21. doi: 10.1096/fasebj.8.10.8050670. FASEB J. 1994. PMID: 8050670 Review.
-
A new turn (or two) for twist.Science. 1996 Jun 7;272(5267):1449-50. doi: 10.1126/science.272.5267.1449. Science. 1996. PMID: 8633234 Review. No abstract available.
Cited by
-
The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.PLoS One. 2010 Feb 23;5(2):e9374. doi: 10.1371/journal.pone.0009374. PLoS One. 2010. PMID: 20186342 Free PMC article.
-
Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe.Neural Dev. 2018 Nov 22;13(1):25. doi: 10.1186/s13064-018-0123-8. Neural Dev. 2018. PMID: 30466475 Free PMC article.
-
Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements.Mol Biol Cell. 2004 Mar;15(3):1185-96. doi: 10.1091/mbc.e03-09-0663. Epub 2004 Jan 12. Mol Biol Cell. 2004. PMID: 14718563 Free PMC article.
-
Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm.Genes Dev. 1998 Dec 15;12(24):3910-22. doi: 10.1101/gad.12.24.3910. Genes Dev. 1998. PMID: 9869644 Free PMC article.
-
Drosophila p53 tumor suppressor directly activates conserved asymmetric stem cell division regulators.iScience. 2024 Oct 9;27(11):111118. doi: 10.1016/j.isci.2024.111118. eCollection 2024 Nov 15. iScience. 2024. PMID: 39524346 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
