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Comparative Study
. 1994 Feb;169(2):248-52.
doi: 10.1093/infdis/169.2.248.

Human parainfluenza virus type 1 evolution combines cocirculation of strains and development of geographically restricted lineages

S V Hetherington  1 , A S Watson, R A Scroggs, A Portner
Affiliations
Comparative Study

Human parainfluenza virus type 1 evolution combines cocirculation of strains and development of geographically restricted lineages

S V Hetherington et al. J Infect Dis. 1994 Feb.

Abstract

The hemagglutinin neuraminidase (HN) glycoprotein of human parainfluenza virus type 1 (HPIV-1) mediates attachment to the host cell and is the target of protective antibody. Since the efficacy of a potential vaccine depends on antigenic constancy, the antigenic and genetic stability of the HPIV-1 HN glycoprotein was examined for 13 isolates obtained between 1981 and 1989. Antigenic analysis with a panel of 11 monoclonal antibodies demonstrated a single change among 3 isolates from 1989 that distinguished them from all other isolates. The HN genes from all 13 isolates and 13 previously published HN gene sequences shared > 95% homology. Evolutionary analysis demonstrated cocirculation of strains, without a dominant lineage. The 1989 isolates and the previously proposed subtype A isolates occupied distinct evolutionary branches, indicating geographically limited evolution. The slow rate of evolution and HN homogeneity may allow development of a single vaccine formulation for the prevention of disease.

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