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. 1981 Apr;38(1):389-92.
doi: 10.1128/JVI.38.1.389-392.1981.

Reovirus inhibition of cellular DNA synthesis: role of the S1 gene

A H Sharpe, B N Fields

Reovirus inhibition of cellular DNA synthesis: role of the S1 gene

A H Sharpe et al. J Virol. 1981 Apr.

Abstract

Type 3 reovirus inhibits L cell DNA synthesis, whereas type 1 reovirus exerts little or no effect on L cell DNA synthesis. By using recombinant viruses containing both type 1 and type 3 double-standard RNA segments, we determined that one double-stranded RNA segment, the reovirus type 3 S1 double-stranded RNA segment which encodes the viral hemagglutinin, segregates with and is responsible for the capacity of reovirus type 3 to inhibit L cell DNA synthesis.

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