Amphotericin B in liposomes: a novel therapy for histoplasmosis
- PMID: 7081822
- DOI: 10.1164/arrd.1982.125.5.610
Amphotericin B in liposomes: a novel therapy for histoplasmosis
Abstract
Incorporation of amphotericin B into liposomes significantly altered its toxicity, tissue distribution, and efficacy. Compared with intravenously administered amphotericin B-desoxycholate, liposome-amphotericin B showed a reduced acute toxicity and a maximal tolerable dose 9 times greater than amphotericin B-desoxycholate. Liposome-amphotericin B also produced higher tissue and lower serum concentrations than amphotericin B-desoxycholate, and was significantly more effective in prolonging survival of mice infected with Histoplasma capsulatum.
Similar articles
-
Experimental chemotherapy of histoplasmosis in nude mice.Am Rev Respir Dis. 1979 Oct;120(4):837-42. doi: 10.1164/arrd.1979.120.4.837. Am Rev Respir Dis. 1979. PMID: 507510
-
Antifungal therapy for central nervous system histoplasmosis, using a newly developed intracranial model of infection.J Infect Dis. 2002 Jun 15;185(12):1830-2. doi: 10.1086/340825. Epub 2002 May 31. J Infect Dis. 2002. PMID: 12085335
-
Amphotericin B lipid complex therapy of experimental fungal infections in mice.Antimicrob Agents Chemother. 1991 Apr;35(4):615-21. doi: 10.1128/AAC.35.4.615. Antimicrob Agents Chemother. 1991. PMID: 2069367 Free PMC article.
-
[Histoplasmosis (infection with Histoplasma capsulatum, capsulatum variety)].Pneumologia. 2005 Apr-Jun;54(2):72-5. Pneumologia. 2005. PMID: 16536005 Review. Romanian.
-
[Disseminated histoplasmosis in AIDS].Dtsch Med Wochenschr. 1994 May 6;119(18):657-62. doi: 10.1055/s-2008-1058744. Dtsch Med Wochenschr. 1994. PMID: 8187612 Review. German.
Cited by
-
A new lipid-based nano formulation of vinorelbine.AAPS PharmSciTech. 2014 Oct;15(5):1138-48. doi: 10.1208/s12249-014-0146-3. Epub 2014 May 29. AAPS PharmSciTech. 2014. PMID: 24871553 Free PMC article.
-
Antibody-based therapeutics for the treatment of human B cell malignancies.Curr Allergy Asthma Rep. 2013 Feb;13(1):33-43. doi: 10.1007/s11882-012-0327-7. Curr Allergy Asthma Rep. 2013. PMID: 23229130 Free PMC article. Review.
-
Optimizing efficacy of Amphotericin B through nanomodification.Int J Nanomedicine. 2007;2(3):301-13. Int J Nanomedicine. 2007. PMID: 18019830 Free PMC article. Review.
-
Optimizing efficacy of amphotericin B through nanomodification.Int J Nanomedicine. 2006;1(4):417-32. doi: 10.2147/nano.2006.1.4.417. Int J Nanomedicine. 2006. PMID: 17722276 Free PMC article. Review.
-
Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.Antimicrob Agents Chemother. 2001 Apr;45(4):1184-91. doi: 10.1128/AAC.45.4.1184-1191.2001. Antimicrob Agents Chemother. 2001. PMID: 11257033 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical