Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia
- PMID: 6982849
- DOI: 10.1007/BF00343314
Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia
Abstract
AKR leukemia cell lines differing in the amount of H-2K and H-2D antigens expressed on the cell surface were used to assess cell-mediated immune responses in syngeneic mice against Gross/AKR murine leukemia virus (MuLV)-induced tumors. Leukemic cells with reduced expression of H-2Kk antigens were inactive as inducers of Gross-MuLV/H-2k-specific cytotoxic T lymphocytes (CTL) and resistant to lysis by CTL raised against H-2Kk positive AKR leukemia cells. H-2Kk positive leukemias induced cytotoxic effectors, which upon restimulation in vitro, lysed the stimulating and other H-2Kk positive leukemia cells. In antibody inhibition experiments, T-cell-mediated cytotoxicity to these leukemias could only be inhibited by antisera and monoclonal antibodies specific for the H-2Kk antigens. Due to this specific role of H-2Kk antigens in T-cell cytotoxicity to Gross/AKR MuLV-induced tumors, reduced expression of H-2Kk antigens on spontaneous AKR leukemic cells could have important implications for surveillance of these neoplastic cells.
Similar articles
-
Resistance to cellular immune response in AKR leukemias.Eur J Immunol. 1986 Jul;16(7):753-9. doi: 10.1002/eji.1830160707. Eur J Immunol. 1986. PMID: 2424771
-
Genetic control of the induction of cytolytic T lymphocyte responses to AKR/Gross viral leukemias. I. H-2-encoded dominant gene control.J Immunol. 1984 May;132(5):2658-64. J Immunol. 1984. PMID: 6425409
-
Genetic control of the induction of cytolytic T lymphocyte responses to AKR/Gross viral leukemias. II. Negative control by the Fv-1 locus in AKR mice of responder H-2b haplotype.J Immunol. 1984 May;132(5):2665-71. J Immunol. 1984. PMID: 6425410
-
Variation in MHC antigenic profiles of tumor cells and its biological effects.Immunol Rev. 1981;60:85-127. doi: 10.1111/j.1600-065x.1981.tb00363.x. Immunol Rev. 1981. PMID: 6171505 Review. No abstract available.
-
Molecular features of the H-2 class I and Qa antigens expressed on Gross virus induced AKR leukaemias.J Immunogenet. 1989 Aug-Oct;16(4-5):329-33. doi: 10.1111/j.1744-313x.1989.tb00479.x. J Immunogenet. 1989. PMID: 2700994 Review. No abstract available.
Cited by
-
Reduction or loss of HLA-A,B,C antigens in colorectal carcinoma appears not to influence survival.Br J Cancer. 1988 Apr;57(4):364-8. doi: 10.1038/bjc.1988.83. Br J Cancer. 1988. PMID: 2839218 Free PMC article.
-
Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene.Mol Cell Biol. 1987 Jan;7(1):305-13. doi: 10.1128/mcb.7.1.305-313.1987. Mol Cell Biol. 1987. PMID: 3561391 Free PMC article.
-
Allogeneic H-2 antigen expression is insufficient for tumor rejection.Proc Natl Acad Sci U S A. 1987 Dec;84(23):8613-7. doi: 10.1073/pnas.84.23.8613. Proc Natl Acad Sci U S A. 1987. PMID: 3500477 Free PMC article.
-
KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells.J Exp Med. 1993 Jun 1;177(6):1651-62. doi: 10.1084/jem.177.6.1651. J Exp Med. 1993. PMID: 8496683 Free PMC article.
-
Deficient expression of class-I HLA in some cases of acute leukemia.Cancer Immunol Immunother. 1984;18(2):91-100. doi: 10.1007/BF00205741. Cancer Immunol Immunother. 1984. PMID: 6239685 Free PMC article.