Coated pits act as molecular filters
- PMID: 6968906
- PMCID: PMC349789
- DOI: 10.1073/pnas.77.7.4156
Coated pits act as molecular filters
Abstract
Two proteins--theta and H63 antigens--are found to be excluded from coated pits on fibroblast plasma membranes. Coated pits thus act as molecular filters, pinching off, into the cell, lipid vesicles containing a limited number of specific receptors but excluding other plasma membrane proteins. This constitutes part of a lipid flow cycle that was proposed earlier to explain the capping of crosslinked surface antigens.
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