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. 1982 Dec;129(6):2612-5.

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset

H C Morse 3rd, W F Davidson, R A Yetter, E D Murphy, J B Roths, R L Coffman
  • PMID: 6815273

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset

H C Morse 3rd et al. J Immunol. 1982 Dec.

Abstract

Mice carrying the Ipr mutation develop massive lymphoadenopathy and severe autoimmune disease. The characteristics of the cell population that proliferates in lymphoid tissues were evaluated by the use of a) monoclonal antibodies and FMF, and b) molecular genetic studies of Ig heavy chain genes. The lymph node cells of different strains of mice homozygous for the Ipr mutation were shown to be almost uniformly Thy-1+, Ly-1+, Ly-2-, H-11+, Ly-5+, sIg-, ThB-, 2C2+, I-A-, 6B2+, and therefore to have surface characteristics of both T and B cells. Molecular genetic studies of the arrangements of Ig heavy chain genes showed that they were not rearranged as in pre-B and B cells. These results suggest that an abnormal proliferating population of T cells in Ipr/Ipr mice aberrantly express B cell surface markers.

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