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. 1984 Nov;81(22):7141-5.
doi: 10.1073/pnas.81.22.7141.

Expression of cellular oncogenes during embryonic and fetal development of the mouse

D J Slamon, M J Cline

Expression of cellular oncogenes during embryonic and fetal development of the mouse

D J Slamon et al. Proc Natl Acad Sci U S A. 1984 Nov.

Abstract

Cellular oncogenes are conserved with great fidelity across a broad span of evolution. This avid conservation suggests possible roles in critical physiologic functions. Little, however, is known about their activity in normal cellular processes. In this study, we examined the expression pattern of eight cellular oncogenes during embryonic and fetal development of the mouse. Five of these genes (c-myc, c-erb, c-Ha-ras, c-src, and c-sis) were expressed at appreciable levels, and four were modulated in a consistent manner during the course of prenatal development.

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