Comparative Study
doi: 10.1126/science.6494925.
Autoimmunity and increased c-myb transcription
- PMID: 6494925
- DOI: 10.1126/science.6494925
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Comparative Study
Autoimmunity and increased c-myb transcription
Science.
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Abstract
A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.
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