doi: 10.1002/ajmg.1320180420.
On the statistical determination of major gene mechanisms in continuous human traits: regressive models
- PMID: 6486171
- DOI: 10.1002/ajmg.1320180420
Item in Clipboard
On the statistical determination of major gene mechanisms in continuous human traits: regressive models
Am J Med Genet.
1984 Aug.
Abstract
We consider the analysis of a continuous trait measured on human families and pedigrees to elucidate the mechanism of underlying major genes. Thinking in terms of the naturally Markovian structure of the dependencies in pedigrees rather than variance components, we describe natural classes of regressive models that are computationally feasible. These models can accommodate wide generalizations of the residual variation, and so should provide a stronger basis than other models proposed to date for inferring the segregation and linkage relationships of major genes.
Similar articles
-
Multifactorial genetic models for quantitative traits in humans.Biometrics. 1979 Mar;35(1):55-68. Biometrics. 1979. PMID: 497338
-
Multivariate and multilocus variance components method, based on structural relationships to assess quantitative trait linkage via SEGPATH.Genet Epidemiol. 2003 Feb;24(2):128-38. doi: 10.1002/gepi.10208. Genet Epidemiol. 2003. PMID: 12548674
-
[Analysis of quantitative trait loci using hybrid pedigrees: quantitative traits of animals].Genetika. 2007 Feb;43(2):265-75. Genetika. 2007. PMID: 17385327 Russian.
-
Segregation analysis: a gene or not a gene. .Prog Clin Biol Res. 1984;147:217-43. Prog Clin Biol Res. 1984. PMID: 6377313 Review. No abstract available.
-
Genetic analysis of multivariate traits.Epilepsy Res Suppl. 1991;4:161-71. Epilepsy Res Suppl. 1991. PMID: 1815598 Review. No abstract available.
Cited by
-
A major gene model of adult height is suggested in Chinese.J Hum Genet. 2004;49(3):148-153. doi: 10.1007/s10038-004-0125-8. Epub 2004 Feb 27. J Hum Genet. 2004. PMID: 14991526
-
Segregation analysis indicates a major gene in the control of interleukine-5 production in humans infected with Schistosoma mansoni.Am J Hum Genet. 1996 Aug;59(2):453-61. Am J Hum Genet. 1996. PMID: 8755934 Free PMC article.
-
Genetic transmission of Alzheimer's disease among families in a Dutch population based study.J Med Genet. 1993 Aug;30(8):640-6. doi: 10.1136/jmg.30.8.640. J Med Genet. 1993. PMID: 8411049 Free PMC article.
-
Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus.Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1877-81. doi: 10.1073/pnas.90.5.1877. Proc Natl Acad Sci U S A. 1993. PMID: 8446602 Free PMC article.
-
Using an age-at-onset phenotype with interval censoring to compare methods of segregation and linkage analysis in a candidate region for elevated systolic blood pressure.BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S84. doi: 10.1186/1471-2156-4-S1-S84. BMC Genet. 2003. PMID: 14975152 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical