Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans
- PMID: 6474093
- DOI: 10.1111/j.1600-0609.1984.tb02390.x
Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans
Abstract
Platelet aggregation was investigated in platelet-rich plasma from normal volunteers before and at various times after intake of 10 analgesic drugs. The drugs used were aspirin, piroxicam, naproxen, indomethacin, diclofenac, ibuprofen, diflunisal, paracetamol and oxyphenbutazone. Aggregation of the platelets was induced by adrenaline or ADP and the first and second waves of aggregation were evaluated. It was found that no drug exerted any effect on the first wave of aggregation. The second wave of aggregation was abolished by aspirin that produced a long-lasting effect for 5-8 d. Piroxicam also abolished the second wave of aggregation and this effect persisted on the 2 following d. Naproxen was normalized in half of the volunteers on the 2nd d. The inhibition caused by indomethacin and diclofenac was corrected on the 2nd d. Ibuprofen and diflunisal produced a definite but short-term effect. The effect of salicylic acid was weak. Paracematol and oxyphenbutazone did not affect platelet aggregation.
Similar articles
-
A randomized, controlled study on the influence of acetaminophen, diclofenac, or naproxen on aspirin-induced inhibition of platelet aggregation.Eur J Pharmacol. 2009 May 1;609(1-3):96-9. doi: 10.1016/j.ejphar.2009.02.042. Epub 2009 Mar 9. Eur J Pharmacol. 2009. PMID: 19272375 Clinical Trial.
-
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.N Engl J Med. 2001 Dec 20;345(25):1809-17. doi: 10.1056/NEJMoa003199. N Engl J Med. 2001. PMID: 11752357 Clinical Trial.
-
Influence of combinations of acetylsalicylic acid, acetaminophen, and diclofenac on platelet aggregation.Eur J Pharmacol. 2008 Oct 24;595(1-3):65-8. doi: 10.1016/j.ejphar.2008.07.036. Epub 2008 Jul 30. Eur J Pharmacol. 2008. PMID: 18700139
-
Non-steroidal anti-inflammatory drugs (NSAID'S) as analgesics in dentistry - a review.J Dent Assoc S Afr. 1983 Jul;38(7):419-26. J Dent Assoc S Afr. 1983. PMID: 6359586 Review. No abstract available.
-
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.Drugs. 1980 Jul;20(1):24-48. doi: 10.2165/00003495-198020010-00002. Drugs. 1980. PMID: 6772422 Review.
Cited by
-
Cyclooxygenase-2 inhibitors: promise or peril?Mediators Inflamm. 2002 Oct;11(5):275-86. doi: 10.1080/09629350290000041. Mediators Inflamm. 2002. PMID: 12467519 Free PMC article. Review.
-
Comparison of Ibuprofen vs Acetaminophen and Severe Bleeding Risk After Pediatric Tonsillectomy: A Noninferiority Randomized Clinical Trial.JAMA Otolaryngol Head Neck Surg. 2019 Jun 1;145(6):494-500. doi: 10.1001/jamaoto.2019.0269. JAMA Otolaryngol Head Neck Surg. 2019. PMID: 30946442 Free PMC article. Clinical Trial.
-
Practical management of the haemorrhagic complications of myeloproliferative neoplasms.Br J Haematol. 2022 Nov;199(3):313-321. doi: 10.1111/bjh.18322. Epub 2022 Jun 20. Br J Haematol. 2022. PMID: 35724983 Free PMC article. Review.
-
Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77. doi: 10.1186/s40360-017-0185-y. BMC Pharmacol Toxicol. 2017. PMID: 29208039 Free PMC article.
-
Enhanced gastric mucosal haemostasis after upper gastrointestinal haemorrhage.Gut. 1991 Jul;32(7):735-9. doi: 10.1136/gut.32.7.735. Gut. 1991. PMID: 1855678 Free PMC article.