Non-A, non-B hepatitis in persistent carriers of hepatitis B virus
- PMID: 6408222
- DOI: 10.1002/jmv.1890110302
Non-A, non-B hepatitis in persistent carriers of hepatitis B virus
Abstract
There are reports in the literature that infection with hepatitis A virus in hepatitis B carriers can result in resolution of the carrier state. In an attempt to induce clearance of the carrier state of hepatitis B virus in two persistently infected chimpanzees, the chimpanzees were infused with documented non-A, non-B infectious material. Biochemical and histopathological evidence of hepatitis was accompanied by the unique abnormalities of endoplasmic reticulum associated with non-A, non-B hepatitis in the chimpanzees. Elevation of alanine aminotransferase was accompanied by fourfold reduction in one chimpanzee and sixfold reduction in the other in the plasma levels of HBV-associated DNA polymerase activity and simultaneously by twofold reduction in the concentration of hepatitis B surface antigen in both chimpanzees. A mediator may account for these changes in markers of hepatitis B virus infection, and this mechanism may also explain the occurrence of spontaneous regression in some persistently infected carriers. The significance of transient red cell anaemia in non-A, non-B hepatitis, which was observed in one of the chimpanzees, is yet to be established.
Similar articles
-
Assay of HBV DNA in the plasma of HBV-carrier chimpanzees superinfected with non-A, non-B hepatitis.J Virol Methods. 1983 May;6(5):295-302. doi: 10.1016/0166-0934(83)90044-7. J Virol Methods. 1983. PMID: 6409916
-
Non-A, non-B hepatitis in chimpanzees: interference with acute hepatitis A virus and chronic hepatitis B virus infections.J Med Virol. 1983;11(3):207-13. doi: 10.1002/jmv.1890110304. J Med Virol. 1983. PMID: 6408224
-
Interference between non-A, non-B and hepatitis B virus infection in chimpanzees.J Med Virol. 1983;11(3):191-205. doi: 10.1002/jmv.1890110303. J Med Virol. 1983. PMID: 6408223
-
Viral markers of hepatitis.Lab Res Methods Biol Med. 1983;7:103-17. Lab Res Methods Biol Med. 1983. PMID: 6413796 Review. No abstract available.
-
Non-A, non-B viral hepatitis.Hum Pathol. 1981 Dec;12(12):1114-22. doi: 10.1016/s0046-8177(81)80332-2. Hum Pathol. 1981. PMID: 6800928 Review.
Cited by
-
Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation.Dig Dis Sci. 1988 Sep;33(9):1185-91. doi: 10.1007/BF01535798. Dig Dis Sci. 1988. PMID: 3044717
-
Clinical and biochemical reactivation of HBV infection in a thalassemic patient after bone marrow transplantation.Infection. 1998 Jan-Feb;26(1):58-60. doi: 10.1007/BF02768759. Infection. 1998. PMID: 9505184
-
Suppression of hepatitis C virus (HCV) replication by hepatitis D virus (HDV) in HIV-infected hemophiliacs with chronic hepatitis B and C.Dig Dis Sci. 1995 Jul;40(7):1583-8. doi: 10.1007/BF02285214. Dig Dis Sci. 1995. PMID: 7628288
-
Dissociation of alanine aminotransferase values in acute hepatitis A patients with and without past experience to the hepatitis B virus.Epidemiol Infect. 1991 Apr;106(2):397-402. doi: 10.1017/s0950268800048548. Epidemiol Infect. 1991. PMID: 2019305 Free PMC article.
-
Hepatitis C virus superinfection in patients with chronic hepatitis B virus infection.J Gastroenterol. 2002;37 Suppl 13:65-8. doi: 10.1007/BF02990102. J Gastroenterol. 2002. PMID: 12109669 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
