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Review
. 1983:28:35-112.
doi: 10.1016/s0065-3527(08)60721-6.

The molecular biology of coronaviruses

L S Sturman, K V Holmes
Review

The molecular biology of coronaviruses

L S Sturman et al. Adv Virus Res. 1983.

Abstract

Coronaviruses have recently emerged as an important group of animal and human pathogens that share a distinctive replicative cycle. Some of the unique characteristics in the replication of coronaviruses include generation of a 3' coterminal-nested set of five or six subgenomic mRNAs, each of which appears to direct the synthesis of one protein. Two virus-specific RNA polymerase activities have been identified. Many of the distinctive features of coronavirus infection and coronavirus-induced diseases may result from the properties of the two coronavirus glycoproteins. The intracellular budding site, which may be important in the establishment and maintenance of persistent infections, appears to be due to the restricted intracytoplasmic migration of the E1 glycoprotein, which acts as a matrix-like transmembrane glycoprotein. E1 also exhibits distinctive behavior by self-aggregating on heating at 100°C in sodium dodecyl sulfate (SDS) and by its interaction with RNA in the viral nucleocapsid. The E1 of mouse hepatitis virus (MHV) is an O-linked glycoprotein, unlike most other viral glycoproteins. Thus, the coronavirus system may be a useful model for the study of synthesis, glycosylation, and transport of O-linked cellular glycoproteins.

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References

    1. Alexander D.J., Collins M.S. Effect of pH on the growth and cytopathogenicity of avian infectious bronchitis virus in chick kidney cells. Arch. Virol. 1975;49:339–348. - PMC - PubMed
    1. Alexander D.J., Collins M.S. The purification and polypeptide composition of avian infectious bronchitis virus. Microbios. 1977;18:87–98. - PubMed
    1. Almeida J.D., Tyrrell D.A.J. The morphology of three previously uncharacterized human respiratory viruses that grow in organ culture. J. Gen. Virol. 1967;1:175–178. - PubMed
    1. Anderson R, Cheley S, Haworth-Hatherell E. Comparison of polypeptides of two strains of murine hepatitis virus. Virology. 1979;97:492–494. - PubMed
    1. Apostolov K, Flewett T.H., Kendal A.P. Morphology of influenza ABC and infectious bronchitis virus (IBV) virions and their replication. In: Barry R.D., Mahy B.W.J., editors. Academic Press; New York: 1970. pp. 3–26. (‘The Biology of Large RNA Viruses’).

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