Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1984 May;45(5):993-9.
doi: 10.1016/S0006-3495(84)84244-7.

Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses

J E Chad, R Eckert
Comparative Study

Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses

J E Chad et al. Biophys J. 1984 May.

Abstract

Computer-assisted modeling of calcium influx through voltage-activated membrane channels predicted that buffer-limited elevation of cytoplasmic free calcium ion concentration occurs within microscopic hemispherical "domains" centered upon the active Ca channels. With increasing depolarization, the number of activated channels, and hence the number of Ca domains, should increase; the single-channel current should, however, decrease, thereby decreasing Ca2+ accumulation in each domain relative to the macroscopic current. Such voltage dependence of the microscopic distribution of Ca2+ may influence relations between total Ca2+ entry and Ca-dependent processes. Ca-mediated inactivation of Ca channels in Aplysia neurons exhibits behavior consistent with the calcium domain hypothesis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Physiol. 1957 Sep 30;138(2):253-81 - PubMed
    1. Nature. 1980 Aug 21;286(5775):816-7 - PubMed
    1. J Neurosci. 1983 Jun;3(6):1263-9 - PubMed
    1. J Physiol. 1983 Mar;336:649-61 - PubMed
    1. Nature. 1982 Sep 9;299(5879):156-8 - PubMed

Publication types

LinkOut - more resources