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. 1983;2(5):763-7.
doi: 10.1002/j.1460-2075.1983.tb01497.x.

Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor

H Schmale, S Heinsohn, D Richter

Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor

H Schmale et al. EMBO J. 1983.

Abstract

The rat arginine vasopressin-neurophysin precursor gene has been isolated from a genomic library cloned in lambda phage Charon 4A. Restriction mapping and nucleotide sequence analysis demonstrated that the gene is 1.85 kilobase pairs long and contains two intervening sequences located in the protein coding region. Exon A encodes a putative signal peptide, the hormone arginine vasopressin and the variable N terminus of the carrier protein neurophysin, exon B encodes the highly conserved middle part of neurophysin and exon C its variable C terminus together with glycoprotein. Thus, the three functional domains of the percursor - arginine, vasopressin, neurophysin, glycoprotein - are encoded on three distinct exons.

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References

    1. Cell. 1981 Jun;24(3):592-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Jan;78(1):243-6 - PubMed
    1. Biochem Biophys Res Commun. 1981 May 29;100(2):901-7 - PubMed
    1. Cell. 1981 Sep;25(3):743-52 - PubMed
    1. Nature. 1982 Jan 21;295(5846):206-8 - PubMed

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