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. 1983 Sep 30;221(4618):1413-5.
doi: 10.1126/science.6310757.

Is cytosolic ionized calcium regulating neutrophil activation?

T Pozzan, D P Lew, C B Wollheim, R Y Tsien

Is cytosolic ionized calcium regulating neutrophil activation?

T Pozzan et al. Science. .

Abstract

The concentration of cytosolic ionized calcium, [Ca2+]i, was measured in intact neutrophils by use of a fluorescent indicator trapped in the icytoplasm. A given rise of [Ca2+]i elicited by the chemotactic peptide formylmethionylleucylphenylalanine (FMLP) was associated with a much greater degree of superoxide generation and myeloperoxidase secretion than was the same or larger [Ca2+]i produced by a specific calcium ionophore, ionomycin, which bypasses cell surface receptors. Thus, FMLP appears to generate some important excitatory signal in addition to a rise in [Ca2+]i and exocytosis and superoxide generation in neutrophils may not be simply dependent on [Ca2+]i as is widely supposed.

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