doi: 10.1038/301038a0.
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene
- PMID: 6296682
- DOI: 10.1038/301038a0
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Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene
Nature.
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Abstract
Only one of six point mutations of the sequence around one end of the larger of the introns of the rabbit beta-globin gene seriously affects the normal removal of the intron and splicing of the gene. That mutation converts a GT sequence, invariably found at the 5' end of introns, into an AT, which is no longer recognized as a signal for intron removal. Instead, three normally unused (cryptic) sites are used, leading to aberrant gene transcripts. One of the cryptic sites is an exception to the invariable GT sequence.
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