Characterization of sarcomeric myosin heavy chain genes
- PMID: 6294119
Item in Clipboard
Characterization of sarcomeric myosin heavy chain genes
J Biol Chem.
.
Free article
Abstract
Myosin heavy chain is encoded by a large multigene family. Using pMHC-25, a recombinant cDNA clone isolated from the rat myogenic cell line L6E9, four members of this family in the rat have been isolated and shown to be tissue-specific and developmentally regulated. The coding regions of these genes share regions of homology interspaced with regions of non-homology. Detailed analysis of one embryonic and one adult myosin heavy chain gene shows that the coding sequences are interrupted by numerous intervening sequences whose number, size, and distribution do not appear to be conserved in the same organism or between species.
Similar articles
-
Sarcomeric myosin heavy chain is coded by a highly conserved multigene family.Proc Natl Acad Sci U S A. 1982 Sep;79(17):5230-4. doi: 10.1073/pnas.79.17.5230. Proc Natl Acad Sci U S A. 1982. PMID: 6291033 Free PMC article.
-
Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain.J Cell Biol. 1989 May;108(5):1791-7. doi: 10.1083/jcb.108.5.1791. J Cell Biol. 1989. PMID: 2715179 Free PMC article.
-
The analysis of a chicken myosin heavy chain cDNA clone.J Biol Chem. 1983 Jun 10;258(11):7149-54. J Biol Chem. 1983. PMID: 6304080
-
Structural analysis of myosin genes using recombinant DNA techniques.J Anim Sci. 1986 Jul;63(1):259-68. doi: 10.2527/jas1986.631259x. J Anim Sci. 1986. PMID: 3525491 Review.
-
Isolation and characterization of a previously unrecognized myosin heavy chain gene present in the Syrian hamster.J Mol Biol. 1991 Apr 20;218(4):657-65. doi: 10.1016/0022-2836(91)90251-z. J Mol Biol. 1991. PMID: 2023240 Review.
Cited by
-
Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.Nucleic Acids Res. 1986 Apr 11;14(7):2951-69. doi: 10.1093/nar/14.7.2951. Nucleic Acids Res. 1986. PMID: 2421254 Free PMC article.
-
Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.Proc Natl Acad Sci U S A. 1990 Feb;87(3):1164-8. doi: 10.1073/pnas.87.3.1164. Proc Natl Acad Sci U S A. 1990. PMID: 1967836 Free PMC article.
-
Evidence for myoblast-extrinsic regulation of slow myosin heavy chain expression during muscle fiber formation in embryonic development.J Cell Biol. 1993 May;121(4):795-810. doi: 10.1083/jcb.121.4.795. J Cell Biol. 1993. PMID: 8491773 Free PMC article.
-
Characterization of genomic clones specifying rabbit alpha- and beta-ventricular myosin heavy chains.Proc Natl Acad Sci U S A. 1984 May;81(10):3044-8. doi: 10.1073/pnas.81.10.3044. Proc Natl Acad Sci U S A. 1984. PMID: 6328491 Free PMC article.
-
Induced formation and maturation of acetylcholine receptor clusters in a defined 3D bio-artificial muscle.Mol Neurobiol. 2013 Dec;48(3):397-403. doi: 10.1007/s12035-013-8412-z. Epub 2013 Jan 31. Mol Neurobiol. 2013. PMID: 23371342 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
