doi: 10.1073/pnas.77.4.1877.
A mechanism for RNA splicing
- PMID: 6246511
- PMCID: PMC348611
- DOI: 10.1073/pnas.77.4.1877
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A mechanism for RNA splicing
Proc Natl Acad Sci U S A.
1980 Apr.
Abstract
The most abundant of the stable small nuclear RNAs of eukaryotic cells, U-1 small nuclear RNA, is exactly complementary to the consensus sequences at RNA splice sites. We propose that this RNA is the recognition component of the nuclear RNA splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing.
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