Role of prostaglandins in acute phase proteins in inflammation
- PMID: 6202298
- DOI: 10.1016/0006-2944(84)90028-0
Role of prostaglandins in acute phase proteins in inflammation
Abstract
Prostaglandin E1, a mediator of inflammation, was investigated for its effects on serum acute phase proteins, alpha 2 macroglobulin (alpha 2M). Induction of carrageenin inflammation in rats caused an elevation of alpha 2M to a maximum level (100%) at 1 day. Similarly, administration of PGE1 (1 mg/kg) was found to increase serum alpha 2M levels in normal rats. On the other hand, sc injection of PGE1 into inflamed rats significantly reduced the alpha 2M in serum as well as edema. In vitro studies with liver slices showed increasing rates of incorporation of [14C]leucine into alpha 2M with the addition of PGE1 to the medium. It was followed by the secretion of alpha 2M-bound radioactivity into media. But addition of higher doses (greater than 100 ng/ml) of PGE1 resulted in the suppression of incorporation and secretion of alpha 2M-bound radioactivity. Incubation of inflamed liver slices with PGE1, however, showed only decreased incorporation and secretion of alpha 2M-bound radioactivity. These results indicate that (a) primary prostaglandins, like PGE1, generated during inflammation may be responsible for the increase of alpha 2M in serum, and (b) PGE1 enhanced the synthesis of alpha 2M in liver and its secretion into the medium, so the anti-inflammatory drugs which decrease levels of PGs are likely to alter alpha 2M levels.
Similar articles
-
Synthesis of acute-phase alpha 2-macroglobulin during inflammation and pregnancy.Ann N Y Acad Sci. 1983;417:117-24. doi: 10.1111/j.1749-6632.1983.tb32856.x. Ann N Y Acad Sci. 1983. PMID: 6200027
-
Induction of rat alpha 2-macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kupffer cell-derived factor.FEBS Lett. 1984 Nov 5;177(1):89-94. doi: 10.1016/0014-5793(84)80987-4. FEBS Lett. 1984. PMID: 6209166
-
Exacerbation of acute pancreatitis in the presence of chronic liver injury in rats, with special reference to therapeutic efficacy of prostaglandin E1.Pancreas. 1999 Aug;19(2):199-204. Pancreas. 1999. PMID: 10438168
-
Alpha 2-macroglobulin and pregnancy zone protein. Serum levels, alpha 2-macroglobulin receptors, cellular synthesis and aspects of function in relation to immunology.Dan Med Bull. 1993 Sep;40(4):409-46. Dan Med Bull. 1993. PMID: 7693397 Review.
-
[Immunological background of plasma protein abnormalities--the relation between inflammation and malignant neoplasm].Rinsho Byori. 1999 Oct;47(10):909-16. Rinsho Byori. 1999. PMID: 10590664 Review. Japanese.
Cited by
-
Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.Molecules. 2009 Jul 3;14(7):2373-93. doi: 10.3390/molecules14072373. Molecules. 2009. PMID: 19633611 Free PMC article. Review.
-
Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective.Iran J Basic Med Sci. 2020 Dec;23(12):1501-1526. doi: 10.22038/IJBMS.2020.44254.10378. Iran J Basic Med Sci. 2020. PMID: 33489024 Free PMC article. Review.
-
A novel MMP-2 inhibitor 3-azidowithaferin A (3-azidoWA) abrogates cancer cell invasion and angiogenesis by modulating extracellular Par-4.PLoS One. 2012;7(9):e44039. doi: 10.1371/journal.pone.0044039. Epub 2012 Sep 4. PLoS One. 2012. PMID: 22962598 Free PMC article.
-
The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup.Mediators Inflamm. 2019 Mar 26;2019:6518308. doi: 10.1155/2019/6518308. eCollection 2019. Mediators Inflamm. 2019. PMID: 31049027 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases