Human cytomegalovirus and herpes simplex type 2 virus in normal and adenocarcinomatous prostate glands
- PMID: 6188872
Human cytomegalovirus and herpes simplex type 2 virus in normal and adenocarcinomatous prostate glands
Abstract
Normal prostate, benign prostate hypertrophy (BHP), and prostate adenocarcinoma (ACP) biopsy specimens were analyzed for the presence of human cytomegalovirus (HCMV) and herpes simplex virus type 2 (HSV-2)-specific macromolecules. HCMV DNA homologous sequences were detected in 2 of 13 normal prostate, 2 of 9 BHP, and 3 of 10 ACP tissues, and HSV-2 DNA homologous sequences were found in 1 normal prostate tissue and 2 ACP tissues. In situ DNA-RNA hybridizations indicated HCMV-specific RNA in 3 of 8 BHP and 4 of 9 ACP tissues. No positive in situ hybridization for HCMV RNA was observed in normal prostate tissues. Parallel in situ DNA-RNA hybridization localized HSV-2-specific RNA in only 1 of 8 tumor sections. No HSV-2-specific RNA was observed in sections of normal and BHP tissues. Anticomplement immunofluorescence (ACIF) tests of BHP and ACP specimens showed specific HCMV immunofluorescence in 3 of 8 BHP and 4 of 9 ACP tissues. ACIF results correlate closely with in situ hybridization results and imply some degree of HCMV association with prostatic abnormality. The results also suggest that latent HCMV may be harbored by the human prostate gland.
Similar articles
-
[Serum antibody levels of cytomegalovirus, herpes simplex type I and adenovirus in patients with benign or malignant prostatic neoplasms].Mikrobiyol Bul. 1986 Jul;20(3):165-75. Mikrobiyol Bul. 1986. PMID: 2436029 Turkish.
-
High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma.J Urol. 2003 Sep;170(3):998-1002. doi: 10.1097/01.ju.0000080263.46164.97. J Urol. 2003. PMID: 12913758
-
Cytomegalovirus and cancer of the prostate: in vitro transformation of human cells.Cancer Treat Rep. 1977 Mar-Apr;61(2):139-46. Cancer Treat Rep. 1977. PMID: 68820
-
Detection of human cytomegalovirus DNA: how, when and where?Scand J Infect Dis Suppl. 1995;99:11-5. Scand J Infect Dis Suppl. 1995. PMID: 8668932 Review.
-
The oncogenicity of human cytomegalovirus.Birth Defects Orig Artic Ser. 1984;20(1):193-211. Birth Defects Orig Artic Ser. 1984. PMID: 6203570 Review. No abstract available.
Cited by
-
Viruses in the mammalian male genital tract and their effects on the reproductive system.Microbiol Mol Biol Rev. 2001 Jun;65(2):208-31 ; first and second pages, table of contents. doi: 10.1128/MMBR.65.2.208-231.2001. Microbiol Mol Biol Rev. 2001. PMID: 11381100 Free PMC article. Review.
-
Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability.Cell Death Differ. 2022 Aug;29(8):1639-1653. doi: 10.1038/s41418-022-00953-w. Epub 2022 Feb 22. Cell Death Differ. 2022. PMID: 35194187 Free PMC article.
-
Inflammatory genetic markers of prostate cancer risk.Cancers (Basel). 2010 Jun 8;2(2):1198-220. doi: 10.3390/cancers2021198. Cancers (Basel). 2010. PMID: 24281113 Free PMC article.
-
Cytomegalovirus prostatitis. Case report and review of the literature.Int Urol Nephrol. 1994;26(5):535-40. doi: 10.1007/BF02767655. Int Urol Nephrol. 1994. PMID: 7860201 Review.
-
Herpes simplex virus type 2 or human herpesvirus 8 infection and prostate cancer risk: A meta-analysis.Biomed Rep. 2013 May;1(3):433-439. doi: 10.3892/br.2013.82. Epub 2013 Mar 19. Biomed Rep. 2013. PMID: 24648964 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources
Medical