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. 1983 Feb 28;111(1):47-54.
doi: 10.1016/s0006-291x(83)80115-6.

Hypomethylation of ras oncogenes in primary human cancers

A P Feinberg, B Vogelstein

Hypomethylation of ras oncogenes in primary human cancers

A P Feinberg et al. Biochem Biophys Res Commun. .

Abstract

We have examined the methylation status of two cellular oncogenes, c-Ha-ras and c-Ki-ras, in primary human carcinomas and the adjacent analogous normal tissues from which the tumors derived. The c-Ha-ras gene was hypomethylated in six of eight carcinomas, including five colonic adenocarcinomas and one small cell lung carcinoma, when compared to adjacent normal tissues. The c-Ki-ras gene was hypomethylated to a lesser extent in two colonic adenocarcinomas. This is the first demonstration of alterations in methylation of cellular oncogenes in human cancer.

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