Demonstration of multiple antigenic sites of the SV40 transplantation rejection antigen by using cytotoxic T lymphocyte clones
- PMID: 6183360
Demonstration of multiple antigenic sites of the SV40 transplantation rejection antigen by using cytotoxic T lymphocyte clones
Abstract
Multiple antigenic sites on the simian virus 40 (SV40) tumor-specific transplantation antigen (TSTA) were detected by the use of cytotoxic T lymphocyte (CTL) clones isolated from continuous cultures of SV40-specific CTL (H-2b). Two independently derived clones, K11 and K19, specific for the SV40 TSTA in association with H-2Db, each recognized a different antigenic determinant of the SV40 TSTA. This conclusion was based on the observation that a human papovavirus BK virus (BKV) transformed cell line, which possesses a T antigen serologically cross-reactive with that of SV40, was lysed by a heterogeneous population of SV40-immune lymphocytes and by clone K19 but not by K11. Therefore, these CTL clones must recognize two different antigenic determinants of the SV40 TSTA:K19 recognizes a cross-reactive determinant of the SV40 and BKV TSTA, whereas K11 is reactive against an SV40-specific determinant.
Similar articles
-
Fine mapping two distinct antigenic sites on simian virus 40 (SV40) T antigen reactive with SV40-specific cytotoxic T-cell clones by using SV40 deletion mutants.J Virol. 1988 Jan;62(1):285-96. doi: 10.1128/JVI.62.1.285-296.1988. J Virol. 1988. PMID: 2446015 Free PMC article.
-
In vitro selection of SV40 T antigen epitope loss variants by site-specific cytotoxic T lymphocyte clones.J Immunol. 1988 Jun 15;140(12):4348-54. J Immunol. 1988. PMID: 2453578
-
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants.J Immunol. 1984 Jul;133(1):433-9. J Immunol. 1984. PMID: 6202788
-
Recognition of simian virus 40 T antigen by cytotoxic T lymphocytes.Mol Biol Med. 1990 Feb;7(1):83-96. Mol Biol Med. 1990. PMID: 2157938 Review.
-
Antigenic structures recognized by cytotoxic T lymphocytes.J Biol Chem. 1991 Feb 25;266(6):3357-60. J Biol Chem. 1991. PMID: 1825310 Review. No abstract available.
Cited by
-
Recognition of influenza virus proteins by cytotoxic T lymphocytes.Immunol Res. 1987;6(1-2):80-100. doi: 10.1007/BF02918106. Immunol Res. 1987. PMID: 2442273 Review. No abstract available.
-
Know thy immune self and non-self: Proteomics informs on the expanse of self and non-self, and how and where they arise.Proteomics. 2021 Dec;21(23-24):e2000143. doi: 10.1002/pmic.202000143. Epub 2021 Aug 9. Proteomics. 2021. PMID: 34310018 Free PMC article. Review.
-
CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors.J Immunol. 2008 Sep 15;181(6):4406-17. doi: 10.4049/jimmunol.181.6.4406. J Immunol. 2008. PMID: 18768900 Free PMC article.
-
Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation.Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1662-7. doi: 10.1073/pnas.0711365105. Epub 2008 Jan 23. Proc Natl Acad Sci U S A. 2008. PMID: 18216248 Free PMC article.
-
Quantitation of CD8(+) T-lymphocyte responses to multiple epitopes from simian virus 40 (SV40) large T antigen in C57BL/6 mice immunized with SV40, SV40 T-antigen-transformed cells, or vaccinia virus recombinants expressing full-length T antigen or epitope minigenes.J Virol. 2000 Aug;74(15):6922-34. doi: 10.1128/jvi.74.15.6922-6934.2000. J Virol. 2000. PMID: 10888631 Free PMC article.