The role of interferon in the resistance of C57BL/6 mice to various doses of herpes simplex virus type 1
- PMID: 6180032
- DOI: 10.1093/infdis/146.3.405
The role of interferon in the resistance of C57BL/6 mice to various doses of herpes simplex virus type 1
Abstract
C57BL/6 (B6) mice are relatively resistant to infection with herpes simplex virus type 1 (HSV-1). Paradoxically, B6 mice were resistant to 250 LD50 (50% lethal dose) of HSV-1 but were killed by 25 or 2.5 LD50 of HSV-1 injected intraperitoneally. At the injection site 250 LD50 of virus induced high titers of interferon (IFN) (greater than 1,000 international units) that reached maximal levels 2-4 hr after inoculation, whereas 25 or 2.5 LD50 of HSV-1 generated only borderline levels of IFN (15-40 international units). Simultaneous inoculation of 250 LD50 of HSV-1 and antiserum to mouse IFN (MuIFN) rendered B6 mice susceptible to infection; however, treatment with antiserum to MuIFN did not increase susceptibility to 1 LD50 of virus. Injections of MuIFN given 2 hr before and 2 hr after inoculation with virus protected B6 mice against 25 LD50 of virus. Thus, endogenous IFN induced after injection with 250 LD50 of HSV-1 protects B6 mice, whereas low doses of virus kill the animals because they do not generate a detectable IFN response at the infection site.
Similar articles
-
The role of natural killer cells and interferon in resistance to acute infection of mice with herpes simplex virus type 1.J Immunol. 1986 May 1;136(9):3481-5. J Immunol. 1986. PMID: 2420892
-
Experimental infection of inbred mice with herpes simplex virus. III. Comparison between newborn and adult C57BL/6 mice.J Gen Virol. 1982 May;60(Pt 1):25-9. doi: 10.1099/0022-1317-60-1-25. J Gen Virol. 1982. PMID: 6178800
-
Experimental infection of inbred mice with herpes simplex virus type 1. I. Investigation of humoral and cellular immunity and of interferon induction.J Gen Virol. 1981 Mar;53(Pt 1):31-8. doi: 10.1099/0022-1317-53-1-31. J Gen Virol. 1981. PMID: 6168735
-
Counteraction of interferon-induced antiviral responses by herpes simplex viruses.Curr Top Microbiol Immunol. 2002;269:171-85. doi: 10.1007/978-3-642-59421-2_11. Curr Top Microbiol Immunol. 2002. PMID: 12224508 Review.
-
Resistance to herpes simplex virus - type 1 (HSV-1).Curr Top Microbiol Immunol. 1981;92:15-24. doi: 10.1007/978-3-642-68069-4_2. Curr Top Microbiol Immunol. 1981. PMID: 6171384 Review. No abstract available.
Cited by
-
The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection.DNA Cell Biol. 2017 May;36(5):329-334. doi: 10.1089/dna.2017.3668. Epub 2017 Mar 9. DNA Cell Biol. 2017. PMID: 28278385 Free PMC article. Review.
-
Macrophages and cytokines in the early defence against herpes simplex virus.Virol J. 2005 Aug 3;2:59. doi: 10.1186/1743-422X-2-59. Virol J. 2005. PMID: 16076403 Free PMC article. Review.
-
Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen.J Exp Med. 1990 May 1;171(5):1469-83. doi: 10.1084/jem.171.5.1469. J Exp Med. 1990. PMID: 2159050 Free PMC article.
-
Innate and adaptive immune responses to herpes simplex virus.Viruses. 2009 Dec;1(3):979-1002. doi: 10.3390/v1030979. Epub 2009 Nov 18. Viruses. 2009. PMID: 21994578 Free PMC article.
-
Experimental infection of inbred mice with herpes simplex virus. VI. Effect of interferon on in vitro virus replication in macrophages.Arch Virol. 1984;82(1-2):83-93. doi: 10.1007/BF01309370. Arch Virol. 1984. PMID: 6208880
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
