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. 1984 Dec;139(2):408-13.
doi: 10.1016/0042-6822(84)90387-8.

Characterisation and physical mapping of an HSV-1 glycoprotein of approximately 115 X 10(3) molecular weight

E A Buckmaster, U Gompels, A Minson

Characterisation and physical mapping of an HSV-1 glycoprotein of approximately 115 X 10(3) molecular weight

E A Buckmaster et al. Virology. 1984 Dec.

Abstract

A type-specific monoclonal antibody that efficiently neutralises HSV-1 immunoprecipitated a glycoprotein of slightly greater electrophoretic mobility than gB from HSV-1 infected cells. Pulse and pulse chase experiments indicate that this glycoprotein is distinct from HSV-1 glycoproteins gB, gC, gD, and gE. This was confirmed by the reactions of LP11 with a series of intertypic recombinants the results of which indicate that the LP11 target gene is located close to the HSV-1 thymidine kinase gene between map positions 0.28 and 0.31. In accordance with the presently agreed convention this glycoprotein should be designated gH-1, and it may correspond to the 110K glycoprotein described by S. D. Showalter, M. Zweig, and B. Hampar (1981), Infect. Immun. 34, 684-692. Antibody LP11 inhibits plaque formation when added to cell monolayers after infection suggesting that gH-1 may play a role in cell-to-cell spread of infectious virus.

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