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. 1977;55(1-6):526-32.
doi: 10.1159/000231966.

Inhibition of specific immune responses by feeding protein antigens

Inhibition of specific immune responses by feeding protein antigens

D G Hanson et al. Int Arch Allergy Appl Immunol. 1977.

Abstract

A profound and long-lasting state of specific immune unresponsiveness may be induced in adult inbred mice given a single dose of protein immunogens--such as ovalbumin or hemocyanin--by the digestive route. The degree of unresponsiveness induced by intragastric exposure to ovalbumin could not be achieved by intravenous injection of deaggregated ovalbumin solutions across a wide range of doses. Unresponsiveness induced by intragastric exposure to hapten-protein conjugates is specific to the carrier protein.

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