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. 1978 Jun;26(3):724-9.
doi: 10.1128/JVI.26.3.724-729.1978.

Noncytopathic mutants of Newcastle disease virus

C H Madansky, M A Bratt

Noncytopathic mutants of Newcastle disease virus

C H Madansky et al. J Virol. 1978 Jun.

Abstract

We have isolated a novel class of mutants of Newcastle disease virus which are less cytopathic than their virulent parent but are still capable of infectious virus production. Unlike wild-type virus, the mutants did not form plaques after 2 days of incubation; they did, however, make hemadsorbing spots. The mutants range in production of infectious virus from 10 to 200% of that of the wild type. They were less cytopathic in a single cycle of infection by light microscopy, loss of protein from the plate, and inhibition of total protein accumulation. All of the mutants exhibited extended mean embryo death times, a correlate of virulence in the adult animal.

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