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. 1975 Dec 20;2(7947):1243-4.
doi: 10.1016/s0140-6736(75)92078-4.

Functional subdivision of islets of Langerhans and possible role of D cells

L Orci, R H Unger

Functional subdivision of islets of Langerhans and possible role of D cells

L Orci et al. Lancet. .

Abstract

Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet--i.e., mostly in its peripheral part--they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.

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