doi: 10.1126/science.183.4124.534.
Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice
- PMID: 4588620
- DOI: 10.1126/science.183.4124.534
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Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice
Science.
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Abstract
Athymic-nude (nu/nu) mice and normal (nu/+) mice showed no differences in either latent period or incidence of local sarcomas or lung adenomas within 120 days after administration of 3-methylcholanthrene at birth. However, nu/nu mice were incapable of rejecting allogeneic skin grafts for the duration of the experiment. These results argue against an active role of thymus-dependent immunity as a surveillance mechanism preventing tumor development.
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