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. 1972 Apr 1;135(4):719-34.
doi: 10.1084/jem.135.4.719.

Granulation tissue as a contractile organ. A study of structure and function

G Gabbiani, B J Hirschel, G B Ryan, P R Statkov, G Majno

Granulation tissue as a contractile organ. A study of structure and function

G Gabbiani et al. J Exp Med. .

Abstract

CONTRACTING GRANULATION TISSUES CONTAIN FIBROBLASTS THAT DEVELOP CHARACTERISTICS TYPICAL OF SMOOTH MUSCLE: (a) They contain an extensive cytoplasmic fibrillar system. (b) They show immunofluorescent labeling of their cytoplasm with human anti-smooth muscle serum. (c) The nuclei show complicated folds and indentations, indicative of cellular contraction. (d) There are cell-to-cell and cell-to-stroma attachments. (e) It is possible to extract similar quantities of actomyosin (having the same adenosine triphosphatase activity) from granulation tissue and from pregnant rat uterus. (f) Strips of granulation tissue, when tested pharmacologically in vitro, behave similarly to smooth muscle. All these data support the view that, under certain conditions, fibroblasts can differentiate into a cell type structurally and functionally similar to smooth muscle and that this cell, the "myo-fibroblast," plays an important role in connective tissue contraction.

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References

    1. Proc Soc Exp Biol Med. 1971 Nov;138(2):466-9 - PubMed
    1. J Ultrastruct Res. 1966 Jun;15(3):389-99 - PubMed
    1. Surg Gynecol Obstet. 1967 Jul;125(1):131-42 - PubMed
    1. Lancet. 1958 Nov 8;2(7054):994-6 - PubMed
    1. J Cell Biol. 1965 Oct;27(1):199-213 - PubMed

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