Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Oct;68(10):2564-8.
doi: 10.1073/pnas.68.10.2564.

Lateral diffusion of phospholipids in a vesicle membrane

R D Kornberg, H M McConnell

Lateral diffusion of phospholipids in a vesicle membrane

R D Kornberg et al. Proc Natl Acad Sci U S A. 1971 Oct.

Abstract

Nuclear-resonance spectra of phosphatidylcholine (PC) vesicles are broadened by spin-labeled PC. The broadening of the N-methyl proton line is proportional to spin-labeled PC concentration; the broadening by 1 molecule in 100 of spin-labeled PC is 9.7 Hz at 35 degrees C; the broadening is not due to collisions between vesicles, exchange of spin label between vesicles, or fusion of vesicles. These findings are proof of rapid diffusion in the plane of the PC bilayer (lateral diffusion). A further study of the broadening reveals the molecular frequency of the translation step for lateral diffusion to be much greater than 3 x 10(3) sec(-1) at 0 degrees C.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 1966 Nov 10;241(21):5044-52 - PubMed
    1. J Lipid Res. 1967 Nov;8(6):551-7 - PubMed
    1. Biochim Biophys Acta. 1968 Jun 11;150(4):666-75 - PubMed
    1. Biochemistry. 1969 Jan;8(1):344-52 - PubMed
    1. Nature. 1969 Sep 6;223(5210):1057-9 - PubMed

Substances

LinkOut - more resources