doi: 10.1126/science.432639.
Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures
- PMID: 432639
- DOI: 10.1126/science.432639
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Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures
Science.
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Abstract
HeLa cells in culture synthesize metallothionein. To investigate the effects of glucocorticoids on metallothionein synthesis we adapted HeLa cells to growth in a defined medium lacking hydrocortisone. In this defined medium, containing 1.5 x 10(-6)M Zn2+, dexamethasone (10(-6)M) caused a five- to sixfold increase in the synthesis of metallothionein. Progesterone (10(-5)M), a known antagonist of glucocorticoids, inhibited this response by 50 percent.
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